The interaction of metallchaperones HypA and UreE facilitates nickel transfer: a “cross-talk” between hydrogenase and urease

Poster-97As a pathogen bacterium found in nearly half of the population, Helicobacter pylori relies heavily on proper function of urease and hydrogenase for its survival and successful pathogenesis[1-3]. Maturation of these two metalloenzymes requires a series of metallochaperones and accessory proteins. Among these, HypA and SlyD have been shown to form complexes with HypB and subsequently to help nickel insertion into hydrogenase[4-7]. Previous study showed that HypA was involved in the maturation of both hydrogenase and urease; unexpectedly, it was also suggested to …postprin